University students’ stress management is a core topic in educational research; however, limited research has ever focused on how personality would impact students’ perception of stress level. Thereby, this quantitative study, based on the Big Five Personality Trait Model, set out to investigates how openness, conscientiousness, extraversion, agreeableness, and neuroticism affect the college students’ perception of their study stress. As a result of a survey with sixty college students in China, it is found that whilst students’ demographic factors may not significantly predict their stress level, psychographic factors including conscientiousness, agreeableness and neuroticism can positively and significantly determine the college students’ perception of stress. Based on the findings of the study, implications for future students’ mental health management and ensuing educational research are put forward.