This article provides an overview of the research and development status of medium-depth disposal in selected foreign countries and summarizes the research progress in China’s medium-depth disposal. Medium depth disposal of radioactive solid waste is the systematic project, and the technique of it is complex, and the influencing factors are various. This article summarizes the status of Medium depth disposals in Sweden, Finland, and Korea. The research status of Medium depth disposal in CHINA, containing the source term, concept study and technological process, and safety case, is put forward. The urgent scientific and technological problems of Medium depth disposal in CHINA, including the source term, site survey, key technologies of overall design, safety case, and standard system, are proposed. This article aims to arouse people to pay a full attention on the research and development of Medium depth disposal, and the study could provide technical reference and suggestions to the follow-up research on Medium depth disposal.