The Pressuremeter Test (PMT) and Standard Penetration Test (SPT) are two important in-situ testing techniques that can objectively reflect the strength and deformation characteristics of soil layers. Establishing regional correlations between soil parameters from PMT and SPT is of great significance in providing reference values for indicators of soil related mechanical properties. Based on drilling data from a new district in Nanjing, this article conducted a statistical analysis of the main physical and mechanical parameters of typical soil layers. The results indicate that there is a good power function relationship between the lateral modulus, horizontal foundation coefficient, and lateral bearing capacity of the soil layer, with a goodness of fit greater than 0.96; There is a linear relationship between the lateral modulus, horizontal subgrade coefficient, lateral bearing capacity, and standard penetration hammer number of soil layers, with a goodness of fit greater than 0.94. The conclusion provides reference for engineering design and scientific research.