Pregnancy induces various physiological adaptations to accommodate the growing fetus. Pregnant women commonly experience changes in gait, balance, and center of gravity, which may increase the risk of falls. This study investigates the effects of negative heel shoes on plantar pressure distribution during walking in third-trimester pregnant women. Twelve healthy primigravidas participated, wearing both flat shoes and negative heel shoes while walking. Plantar pressure data were collected using the Pedar-X® insole system. Results revealed that negative heel shoes significantly reduced maximum force in the medial forefoot regions compared to flat shoes, and the force-time integral only significantly decreased in the medial forefoot region. Wearing negative-heeled shoes resulted in an increase in peak force in the hallux region. The study suggests that modifying heel-toe drop in shoes can effectively mitigate plantar pressure during third-trimester pregnancy, reducing the risk of forefoot discomfort and potential injuries. Negative heel shoes could be beneficial for pregnant women, offering a solution to alleviate forefoot pressure and promote foot blood circulation during walking. However, further optimization is needed in the hallux region for negative heel shoes.