Knowledge graphs are generating significant interest in industry and research. These graphs can be enriched with data to represent aspects of production systems such as their structure, component interrelationships, and conditions. This provides opportunities to gain insights into system behavior, performance, and states. Such insights could potentially be leveraged by a wide range of technologies for a multitude of purposes and applications such as system control, process optimization, and informed decision making. However, the existing literature addressing industrial applications of knowledge graphs related to production systems remains limited in scope and depth. This underscores the importance of developing methods for exploring the potential use and implementation of knowledge graphs in such systems. The primary focus of this study centers on facilitating such exploration by developing a virtual commissioning simulation framework. A modular production system is modelled that leverages physics, moving product dynamics, and incorporates authentic PLC and robot programs. A knowledge graph is integrated and enriched with data representing various aspects of the system. An application is developed to facilitate product routing and prioritization. A service-oriented approach is used that leverages graph data processing and exchange for service registration and matching. System simulations are conducted and subsequently the framework is evaluated for outcomes and findings. This study demonstrates the successful design and implementation of a production system simulation framework that uses knowledge graphs for system functionality. It demonstrates the exploration of knowledge graph applications through the development of a modular and service-oriented system that includes system functionality supported by the graph. The results highlight the potential of simulation suggesting its capacity for valuable exploration regarding potential applications of knowledge graphs within production systems.