The high turnover rate of Tibetan cadres has seriously affected the development of Tibet. Existing studies have mainly explored the turnover of rural teachers, and primary and secondary school teachers, and have paid less attention to the extra-occupational factors. In this paper, we take teachers and civil servants working on the Tibetan Plateau as examples to explore the turnover problems, and analyze their mediating and moderating mechanisms. The study finds that psychological contract breakdown significantly and positively affects the turnover intention of Tibetan cadres, while job satisfaction, job embeddedness, and perceived opportunities play a mediating role, and kinship responsibility moderates the relationship between job satisfaction, job embeddedness, and turnover intention. The results of this study expand the antecedents of job embeddedness theory and turnover modeling studies, enrich the mediation and boundary mechanisms of turnover research, explain the reason and internal mechanism of Tibetan cadres leaving and retention, and provide ideas for Tibetan cadres’ retention.