Laser-powder bed fusion LPBF techniques can be used to manufacture complex-shaped, thin-walled, hollow, or slender parts. Although the dimensions of the generated components are close to the final measurements, additional machining processes are required to obtain the desired surface finish and dimensional tolerance. The melt pool dynamic during the LPBF operation results in directional gain structures in alloys. The resulting mechanical properties are strongly dependent on the component build orientation, which can affect the machinability of the produced part. This review paper provides knowledge on the role of microstructure in the machinability of LPBF-produced IN718. The effect of grain shape and distribution, grain boundary density on the surface integrity, and resulting cutting forces are investigated.