Considering the factor of wind load, this study explores the engineering application of prefabricated assembled partition walls in underground stations. Using the finite element analysis software ANSYS, we simulate the displacement deformation and mechanical behavior of the assembled partition wall in the station under the action of wind load. At the same time, the mechanical characteristics of the assembled partition wall under the consideration of only self-weight factors are also used as a comparison to further analyze the main cause of partition deformation. We also extract the displacement data of the assembled partition wall in actual engineering and compare it with the numerical values obtained from the simulation software, providing theoretical support for actual engineering, and verifying the feasibility of ANSYS in engineering applications. The following conclusions are drawn self-weight is the main cause of partition deformation; the position and size of the holes directly affect the structural performance of the wall; the prefabricated assembled wall can meet the actual engineering needs of the subway.