A Modified-FWO-Algorithm was proposed to modify the drawbacks of the traditional FWO-Algorithm throughout the construction of incineration kinetics model for complex pollutants. And the implementation process of this algorithm was introduced via the construction of amphotericin residue incineration kinetic model. The results indicate that two stages emerged in TG/DTG analysis of amphotericin residue, and reactions related to those stages are both multi-step reaction. “White-Box” incineration kinetic model established on Modified-FWO-Algorithm possessed the lowest RMSE value was 0.43%. Data reproducibility of the model derived Modified-FWO-Algorithm was 24.54 times higher than established by FWO-Algorithm.