Aiming at the serious problem of dust pollution in blasting work, the dust generation law and dust-bearing air flow time and space evolution law of blasting working face is analyzed and studied, and the optimal dust-exhausting wind speed of blasting work was 1.5 m/s. Combining with the dust production characteristics and wind speed conditions of the 107 blasting face in Dongling Coal Mine, Chongqing, Comprehensive dust prevention measures such as high-efficiency water cannon mud, high-pressure spray dust reduction, and dust concentration over-limit spray dust reduction are adopted to control the dust from the source and cut off the dust diffusion path, and the total dust reduction efficiency reached 94.8%, the respirable dust reduction efficiency reached 92%, and a good dust reduction effect has been achieved, which provides a basic basis for the control of dust in the blast mining work.