We live in a world where companies are shifting to the industry 4.0 paradigm. One of the pillars of Industry 4.0 is the digitalization of physical assets and manufacturing processes, moving toward the Cyber-Physical Production Systems concept (CPPS). In these systems, every component of the production process – machines, tools, workstations, etc. – is equipped with sensors, possesses information about itself, and can interact with each other, allowing the production of smaller batches at lower prices and increase product customization through adaptative processes. Consequently, companies are evolving their information systems to have more visibility and control over their production systems. This change increases both the production system’s agility and its vulnerability to communication and information related disruptions. Hence, companies that adhere to Industry 4.0 enabling technologies must adopt new methodologies and tools to become aware of the new risks that arise by the introduction of new digital platforms, their impacts in the production systems, and how they may react to remain resilient. In this paper, disruption events and adequate mitigation strategies are analysed, modelled, and simulated as part of a methodology designed to measure the impacts of disruptive events on the production system.