The analysis of biomedical signals performs an important role in figuring out numerous issues in clinical science. Also, the urge to track biomedical signals in fitness and well-being control is progressively growing with the multiplied occurrence of persistent sicknesses over the last decade. By nature, the most of the real-time signals are analog. Hence, an Analog to digital converter (ADC) is required to transform the signal. In ADC architecture, the comparator is the essential block that performs a vital role and consumes greater power in ADC design. Numerous architectures for comparators relate to biomedical programs are mentioned in recent days. In this paper, the exceptional latest techniques of comparator designs are discussed with their key capabilities in conjunction with pros and cons.