At present, fractional differential is the effective mathematical approach which deals with the factual problems. This projected technique employs the fractional derivatives definitions Riemann-Liouville (R-L), Grunwald-Letnikov (G-L) and the caputo technique for denoising medical image. The presented method based on fractional derivative which in turn improves the quality of image. The input image is processed on integer order method such as pre-processing operation, image conversion and noise image. The fractional differential mask method is to be applied with the help of Riemann Liouville, and Caputo algorithm. After denoising the medical image enhanced using Anisotropic diffusion process and the result is analyzed to finally get denoised and predicted image.