Research and training programs in Medical Informatics and Telemedicine offered at the Politecnico di Milano are summarized. The educational pathways refer to the programs of the 5-years based Laurea Degree, the 3-years based Diploma Universitario Degree, of the post-Laurea 3-years-based Doctoral Degree and of the 1- year based Master Degree, as well as of the Continuing Education Program. The Research programs focus on databases and extend to the optimisation of the “Visible Human Dataset - Milano Mirror Site” services. Additional activities relate to standardization at both Italian and European levels and to cooperations with hospitals and manufacturers.