Objectives: To gather end-user feedback and evaluate factors that influence end-user satisfaction of order entry systems used in the hospitals under National Healthcare Group, Singapore. Design: Questionnaires were sent to a randomly selected group of 100 doctors and nurses. Results & Conclusions: 52 doctors and nurses responded to the survey. The users' satisfaction with the clinical systems was average. (Mean satisfaction score is 3.85 on a scale of 1 to 7). Users generally agree that the systems could help reduce patient care errors and improve delivery of quality care to patients. System reliability, intuitive navigational capabilities and ease of use are strongly and positively correlated with user satisfaction. System response time however, is found to be strongly but negatively correlated with user satisfaction with a correlation coefficient of −0.717 (p<0.001). These findings suggest that more efforts should be made to improve these aspects in order to improve user satisfaction. These elements should also form important considerations in all future clinical systems development.