The present study shows a procedure for liquefaction hazard mapping in consideration of global climate change has been proposed and its application of the method to vulnerability assessment to seismic geo-hazard induced by global climate change in a coastal region has been described. The objective region in this study is lowland that lies between the Tama river and Tsurumi river in Yokohama and Kawasaki city, Japan. There are approximately 700 locations of site investigations in the geo-information database. These data have been used for the groundwater flow analysis and liquefaction hazard. Finally, Vulnerability to liquefaction hazard in the objective region has been assessed by comparison of liquefaction hazard maps in the present situation and the future affected by global climate change.