Geotechnical earthquake engineering hazards have consequences that are difficult to mitigate, especially for infrastructure systems with multiple and distributed components. In the last few decades significant progress has been made to provide more accurate and useful methods to evaluate hazards for complex systems. This research developed a GIS methodology to be used as a “screening tool” to evaluate geotechnical earthquake engineering hazards from a database of borehole data and then display the results on a map. The methodology was customized within the GIS environment to calculate both the liquefaction potential and a ground motion magnification factor from borehole data and ground motion time histories, using well established procedures. The results are then displayed spatially for screening purposes, or manual inspection and analyses by the engineer. A pilot study was conducted for a series of boreholes along the highway system near Poplar Bluff, Missouri, using two different New Madrid seismic events. The results for this pilot study show that this type of screening tool could be advantageous for state and federal agencies responsible for earthquake resilient infrastructure systems.