Placed at conjunction of four tectonic blocks which lie on the edge of the Eurasian plate, Vrancea zone in Romania is considered one of the most seismically active area in Europe, being characterized by strong intermediate depth seismicity in a very limited and well defined hypocentral region.The joint analysis of geodetic, seismological, geological and time-series satellite data (LANDSAT MSS, TM and ETM, SAR-ERS 1/2, ASTER, MODIS) is revealing new insights in the understanding of the kinematics and dynamics of the complex plate boundary system and long-term deformation in relation with earthquake activity. Multispectral and multitemporal satellite images over a period 1975–2005 have been analyzed for recognizing the continuity and regional relationships of active faults as well as for geologic and seismic hazard mapping. Seismic hazard maps and classifications of different geologic features and Digital Elevation Models (DEM) generation from SAR ERS1/2, Landsat TM, ETM, and ASTER data are highly correlated with in-situ ground data. GPS measurements provide information on the rate of strain accumulation on active faults (coseismic, postseismic, and interseismic deformation; plate motion and crustal deformation at plate boundaries). Based on GPS Romanian network stations data was revealed a displacement of about 5 or 6 millimeters per year in horizontal direction relative motion, and a few millimeters per year in vertical direction. Future use of long-term InSAR data will be a useful tool in active tectonic investigation for this region.