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Relationship Between the Gut Microbiota and Alzheimer’s Disease: A Systematic Review
Elisa Marina González Cordero, Miguel Angel Cuevas-Budhart, Diana Pérez Morán, Miguel Angel Trejo Villeda, Mercedes Gomez-Del-Pulgar Ga-Madrid
391 - 400
10.3233/AIAD220024
Research Article
Advances in Alzheimer's Disease
Volume 9: Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease
Abstract

Background:

In recent years, scientific research on the gut microbiota and their relationship with some diseases, including neurological ones, has notably increased. As a result of these investigations, the so-called gut-brain axis arises. Despite its influence on the evolution and development of cognitive impairment, the gut-brain axis is little defined and demonstrated.

Objective:

To provide the best scientific evidence available on the relationship between the gut microbiota and Alzheimer’s disease.

Method:

Systematic and narrative review of the information generated in the last 5 years in national and international databases, in English and Spanish.

Results:

Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review.

Conclusion:

The results of these studies support the hypothesis that there is a relationship between the gut microbiota and cognitive disorders through the gut-brain axis. However, today, there is a substantial lack of human studies, especially clinical trials, which makes it difficult to formulate clinical recommendations on this topic.

$35.00 / €27.50 / £22.00
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