The objective of this chapter will be a key reference for researchers in the field of HIV/AIDS research with huge amount of data collection across the world with medical and all general information related to HIV/AIDS research. It overcomes (replaces) the existing system huge data management, processing problems with Big Data Analytics. This chapter provides the current HIV/AIDS research activities, issues and solutions, government policies and census information across the world. Also provides and concludes the information regarding HIV/AIDS Big Data Analytics, Models, Security and Privacy features, Big Data management techniques, quick decision making approach, Algorithms for the Prediction, Classification, Visualization, Clustering, Optimization and Distributed Processing problems and future scope.