This article presents a risk modeling in buildings by landslides triggered by earthquakes and rainfall in the city of Medellin using a geographic information system (GIS). For this, a computer model that considers topographic, geological, geotechnical and hydrological characteristics of the study area was implemented to determine landslide hazard by evaluating the stability of slopes using pseudo static Newmark Method, including a probabilistic approach technique based on the first order and second moment -FOSM-. The approach for the assessment of physical vulnerability of buildings in the study area was conducted through structural fragility indexes that consider the definition of the level of damage to buildings through event trees using a cadastral inventory data of the municipality of Medellin. The routine calculates the probability of a landslide to occur given that an earthquake produces a horizontal ground acceleration (Ah), considering the uncertainty of the geotechnical parameters and the conditions of soil saturation for the effect of previous rainfall in the area, then multiply such values with the structural fragility indexes values in order to estimate the damage indices of buildings, which are associated with the risk when considering the relevant economic variable to the replacement value of such structures from assessed values. The implemented model is able to quantify the risk caused by this type of disaster in an area of the city considering different values of Ah, and also an analysis of the costs arising from damage to the houses in the study area was carried out under different scenarios and structural conditions in which it was found that under an assumed scenario in which all the buildings in the study area meet the requirements of the Colombian Standard for Design and Construction Earthquake Resistant, reducing the costs arising by the effect of a disaster sliding round the order of 70% compared to the condition of the actual structural scenario to the maximum horizontal ground acceleration expected in the city for an earthquake with a return period of 475 years according to the study of seismic microzonation in 2002.