The pars interarticularis lesions in isthmic spondylolisthesis result generally from mechanical stresses in the neural arch due to repetitive overload during daily activities or to trunk imbalance resulting from spino-pelvic morphology. The L5-pelvis junction of a low-grade isthmic spondylolisthesis patient was modeled using a personalized finite element model to investigate the biomechanical behavior of the L5-S1 motion segment. Stress distribution and facet contact pressure in the altered segment were analyzed under 500 N simulating the gravitational load. High von Mises stresses were located in the pars interarticularis, in the pedicle, and in the outer region of the annulus. A high contact pressure was obtained at the facet surfaces. Influenced by the pelvic morphology, the inclination of L5-S1 junction affects the resulting shear forces and may play a crucial role in spondylolisthesis development.