In the fight against New Coronary Pneumonia Epidemic, Chinese Ministry of Health put forward the inevitable requirements of precise policy implementation and scientific epidemic prevention. Accordingly, the big data technology has been applied in the analysis of epidemic dynamic, information inquiry, disease prevention and treatment, and prediction of epidemic trend. And, great success has been achieved in the fight, where the big data technology has played a vital role. This article outlines the main applications of big data technology in the prevention and control of New Coronary Pneumonia Epidemic, and proposes suggestions based on the problems in the application of big data during the epidemic prevention and control period. In the later stage, the integration of big data technology in various fields should be accelerated, information should be further shared and the utility value of data should be maximized.