We investigated the use of hospital information systems (HIS) among nurses and its effect on their individual performance. We combined UTAUT and Delone & McLean models and developed a questionaire and collected 173 questionaires from nurses. We found that effort expectancy, information quality, performance expectancy and system quality positively influence nurses’ intention to use HIS. In addition, nurses’ intention to use and facilitators conditions positively direct their actual use. Information quality, service quality and system quality significantly increase nurses’ satisfaction with HIS. Lastly, nurses’ satisfaction with HIS and their actual use positively improves their individual performance in working with HIS.