A kind of biopolymer microsphere based on halloysite nanotubes (HNTs) were loaded insulin for oral administration.
In order to increase the bioavailability of insulin and overcome the gastrointestinal (GI) enzymatic degradation for delivery of insulin by oral administrationfor the treatment of diabetes.
Fourier Transform Infrared (FTIR), X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscopy (SEM), swelling property, release profiles, biocompatibility, acute oral toxicity and HE staining were tested.
INS could be successfully loaded on the HNTs, and the biopolymer microspheres exhibited an egg-box structure which contributed INS loading. Besides, composite microspheres with smart a pH responsive act as an insulin delivery system.
The intelligent pH response system for oral delivery of insulin was a relatively safe and effective drug delivery system, and it has great potential to achieve insulin oral administration for the treatment of diabetes.
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