A kind of biopolymer microsphere based on halloysite nanotubes (HNTs) were loaded insulin for oral administration.
In order to increase the bioavailability of insulin and overcome the gastrointestinal (GI) enzymatic degradation for delivery of insulin by oral administrationfor the treatment of diabetes.
Fourier Transform Infrared (FTIR), X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscopy (SEM), swelling property, release profiles, biocompatibility, acute oral toxicity and HE staining were tested.
INS could be successfully loaded on the HNTs, and the biopolymer microspheres exhibited an egg-box structure which contributed INS loading. Besides, composite microspheres with smart a pH responsive act as an insulin delivery system.
The intelligent pH response system for oral delivery of insulin was a relatively safe and effective drug delivery system, and it has great potential to achieve insulin oral administration for the treatment of diabetes.
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
Tel.: +1 703 830 6300
Fax: +1 703 830 2300 firstname.lastname@example.org
(Corporate matters and books only) IOS Press c/o Accucoms US, Inc.
For North America Sales and Customer Service
West Point Commons
Lansdale PA 19446
Tel.: +1 866 855 8967
Fax: +1 215 660 5042 email@example.com