Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns. It is of critical importance for clearing invading pathogens and controlling bacterial infections through modulating inflammation. However, excessive host inflammatory responses may trigger organ failure, disrupt tissue homeostasis and induce immune disorders. Emerging evidence has shown that Notch signaling interacts with components of TLRs and participates in regulating immune responses. In this review, we discussed how Notch pathways interact with TLRs pathway and how these two pathways coordinate to regulate immune response, particularly polarization of macrophages, differentiation of dendritic cells, activation of T cell subsets.
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
Tel.: +1 703 830 6300
Fax: +1 703 830 2300 firstname.lastname@example.org
(Corporate matters and books only) IOS Press c/o Accucoms US, Inc.
For North America Sales and Customer Service
West Point Commons
Lansdale PA 19446
Tel.: +1 866 855 8967
Fax: +1 215 660 5042 email@example.com