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Hospital readmissions receive increasing interest, since they are burdensome for patients and costly for healthcare providers. For the calculation of reimbursement fees, in Germany there is the German-Diagnosis Related Groups (G-DRG) system. For every hospital stay, data are collected as a so-called “case”, as the basis for the subsequent reimbursement calculations (“§21 dataset”). Merging rules lead to a loss of information in §21 datasets. We applied machine learning to §21 datasets and evaluated the influence of case merging for the resulting accuracy of readmission risk prediction. Data from 478,966 cases were analysed by applying a random forest. Many cases with readmissions within 30 days had been merged and thus their prediction required additional data. Using 10-fold cross validation, the prediction for readmissions within 31–60 days showed no notable difference in the area under the ROC curves comparing unedited §21 datasets with §21 datasets with restored original cases. The achieved AUC values of 0.69 lie in a similar range as the values of comparable state-of-the-art models. We conclude that dealing with merged cases, i.e. adding data, is required for 30-day-readmission prediction, whereas un-merging brings no improvement for the readmission prediction of period beyond 30 days.
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