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The purpose of this study was to investigate the effect of nursing information system (NIS) on clinical performance from the perspective of nurses in an academic hospital affiliated to Mashhad University of Medical Sciences in Iran. This descriptive cross-sectional study was conducted in 2016. We collected data targeting nurses with over three years' experience in using the NIS (120 nurses). NIS had caused improvement in “accuracy the consistency of drug, lab tests and radiology requests”, “increasing the speed of the automated extracting of minimum data set for decision making and care trends” with the means of 4.89 and 4.27 respectively (5 point Likert). Findings showed that “workload of nurses” (Mean 4.05), “duplication in recording patients' information” (Mean = 3.99) obtained the highest mean. Furthermore, “appropriateness of the data entry tools to tasks” (Mean=3.29) and “the ability of adapting the software to new responsibilities of nurses “(Mean=3.25) gained the lowest mean.
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