Background: Machine learning algorithms are a promising approach to help physicians to deal with the ever increasing amount of data collected in healthcare each day. However, interpretation of suggestions derived from predictive models can be difficult.

Objectives: The aim of this work was to quantify the influence of a specific feature on an individual decision proposed by a random forest (RF).

Methods: For each decision tree within the RF, the influence of each feature on a specific decision (FID) was quantified. For each feature, changes in outcome value due to the feature were summarized along the path. Results from all the trees in the RF were statistically merged. The ratio of FID to the respective feature's global importance was calculated (FIDrel).

Results: Global feature importance, FID and FIDrel significantly differed, depending on the individual input data. Therefore, we suggest to present the most important features as determined for FID and for FIDrel, whenever results of a RF are visualized.

Conclusion: Feature influence on a specific decision can be quantified in RFs. Further studies will be necessary to evaluate our approach in a real world scenario.