A sensor network is key infrastructure for advancing a hospital information system (HIS). The authors proposed a method to provide roaming functionality for Bluetooth to realize a Bluetooth-based sensor network, which is suitable to connect clinical devices. The proposed method makes the average response time of a Bluetooth connection less than one second by making the master device repeat the inquiry process endlessly and modifies parameters of the inquiry process. The authors applied the developed sensor network for daily clinical activities in an university hospital, and confirmed the stabilitya and effectiveness of the sensor network. As Bluetooth becomes a quite common wireless interface for medical devices, the proposed protocol that realizes Bluetooth-based sensor network enables HIS to equip various clinical devices and, consequently, lets information and communication technologies advance clinical services.