The key aim of this chapter is to introduce the complex, multi-mode research methodology the HANDS system has been tested by in terms of its efficiency and applicability, to point to the considerations that motivated this methodology, to summarize the major conclusions it served with, and to make some conclusive recommendations for similar future developments as well as for their field testing. Thus, the first part of the chapter is a brief outline of the contexts of, and methodological dilemmas related to, the non-trivial task of testing a mobile cognitive support system designed specifically for individuals with autism spectrum disorders. Then an overview of the scheme of the mixed mode methodology applied in the HANDS project is presented. As this scheme is based on cooperation between methodologically autonomous research streams, this section introduces briefly the designs and methods used by the three strands. The third part of the chapter is a brief overview of a few key research findings from two of the above research streams (Cognitive Psychology and Applicability in the Learning Environment) – both of those results that arose specific research streams and of those that came from integrated interpretations. Part four then presents two brief case studies where quantitative and qualitative data are drawn together to illustrate both the complexity of factors influencing usage efficiency and user experience, but also the productivity of multi-mode methods. Our results altogether suggest that – adequate institutional and technological background and pedagogical embedding provided – the HANDS system can be an efficient element in the toolset for supporting young people on the autism spectrum, as its use is able, in selected cases, to enhance their social, self management and daily life skills. Our complex research design has proven to be highly productive in revealing positive effects as well as their contextual preconditions and some key limitations. Based on these results, the closing part of the chapter focuses on future perspectives, in two ways: what are the vistas for further development of similar support systems and in what ways the overall successful methodological approach could be further improved.