Regional Healthcare System Authorities (RHSAs) run under the Ministry of Health and Welfare in Greece, aim is to improve the level of quality that health care organizations offer as well as to control the expenditure of health care services provided by the health care organizations. In this article we present the considerations taken during the establishment of the first Regional Contact & Service Center for Public Health in Greece in two of the RHSAs. In this respect, the current piece of work provides an up-to-date experience in establishing and setting the RCSC in its organizational context, an outline of its conceptual model and design, an outlook of the first quarterly results of its use, and a discussion of its potential impact.