The diagnostic variability in pathology, widely reported in the literature, is partly due to the use of different classification systems by pathologists. The descriptions of morphological characteristics on the same image within different classification systems can be considered as different points of view of pathologists. Our aim is to represent the points of view of the experts in pathology during image interpretation and to propose a methodological and technical solution in order to implement interoperability between these points of view. According to the hybrid ontology approach, we developed a system in three stages consisting in 1) the representation of the various points of view in local ontologies 2) the realization of a shared vocabulary and the development of a mapping tool used to allow the matching of local ontologies and shared vocabulary 3) the development of a transcoding algorithm for the translation of a case description from one point of view to another. A first evaluation of the transcoding algorithm was conducted for 33 cases of breast pathology. Our results show that the pathologists generally produce descriptions of the cases which do not follow rigorously the interpretation rules corresponding to the point of view they assert to adopt. While most of the concepts of local ontologies can be transcoded from a local ontology to another one (varying from 62.5 % to 100% according to the local ontology), the transcoding of a description which is valid according to a certain point of view, often results in a description which is not rigorously in accordance with the new point of view. These results underline the differences of interpretation rules existing in the different points of view.
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