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Clinical Decision Support to Implement CYP2D6 Drug-Gene Interaction
Pedro J. Caraballo, Mark Parkulo, David Blair, Michelle Elliott, Cloann Schultz, Joseph Sutton, Padma Rao, Jamie Bruflat, Robert Bleimeyer, John Crooks, Donald Gabrielson, Wayne Nicholson, Carolyn Rohrer Vitek, Kelly Wix, Suzette J. Bielinski, Jyotishman Pathak, Iftikhar Kullo
The level of CYP2D6 metabolic activity can be predicted by pharmacogenomic testing, and concomitant use of clinical decision support has the potential to prevent adverse effects from those drugs metabolized by this enzyme. Our initial findings after implementation of clinical decision support alerts integrated in the electronic health records suggest high feasibility, but also identify important challenges.
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