Communication is a core aspect of the human life, since it makes us able to share concepts, information and needs. In patients afflicted by pathologies like Amyotrophic Lateral Sclerosis (ALS) an interruption of communication ability occurs: the patient must use Alternative and Augmentative Communication (AAC) aids to recover this capability. Due to the progress of the disease, the patient's abilities keep reducing, till complete paralysis. In that condition the only interface able to provide a communication channel is Brain Computer Interface (BCI). In the following we will present a P300-based BCI, integrated in a project implementing a remote monitoring system for ALS patients.