The application of nanotechnology in geotechnical engineering is a novel concept, in which there are little investigations in this scope. The use of this technology in some talented fields such as soil improvement, seepage and grouting will offer great advantages in geotechnics. In this way, the stabilization of a low plasticity clay soil was investigated using nanomaterial in this study. The weak soil was extracted from Boodian Road in North of Iran. The numbers of 80 unconfined compression strength (UCS) tests were performed in this research. At the first part, the effect of lime on the enhancement of the original soil was studied. The results demonstrated the little effect of lime in the soil improvement. At the second part, the effect of nano-silica was investigated on the stabilization of the soil-lime mixture. The selection of this nanomaterial was based on the XRD and XRF tests on the original soil. The results illustrated the meaningful and significant effect of nano-silica in the soil-lime mixture, in which adding nano-silica increased the strength of the soil and soil-lime mixture up to 7.5 and 3 times respectively. The effects of curing time were also evaluated in this study and the results showed that the strength of the soil-lime mixture increases more rapidly with adding nano-material. In this research, the optimum mixture design for stabilization of the Boodian weak soil was selected as 5% lime and 3% nano-silica into the soil.