This article highlights the potential of the application of the cause-effect model for the ergonomic evaluation in the field of cushions. User involvement in the prescription and development of assistive devices have been identified a key aspect for positive interventions, although the reality is that we lack of systematic approaches and examples of best practices. The potential benefits are identified for the development of new products and in the prescription process. Additional research would be necessary to better link the characteristics of the cushions and users with the biomechanical and physiological performance of the interface cushion-user and the consequences measured in health, user perception and activity performance. This article shows examples of the relationship in this three levels from the point of view of the user perception.